Interactive scientific illustration of the cell types with the tumor microenvironment where a reopened blood vessel allows a drug to diffuse into the tissue.
Myeloid-Derived Suppressor cells (MDSCs)

Immunosuppressive MDSCs are recruited to the tumor microenvironment. TLR9 agonists have been shown to reprogram and eliminate MDSCs, reducing their immunosuppressive effects.6 1 of 4 Natural Killer (NK) Cells

In tumors, NK cells are suppressed through various pathways but have shown reactivation upon TLR9 stimulation.6 2 of 4 Toll-Like Receptor 9 (TLR9) Agonists

TLR9 agonists have the potential to activate the immune system and promote anti-tumor activity through activation and modulation of immune cells. 1–5 3 of 4 Plasmacytoid Dendritic Cells (pDCs)

pDCs are suppressed in the tumor microenvironment (TME) but have shown reactivation through TLR9.6 4 of 4
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