Publications & Presentations

Scientific publications and presentations reflect the quality of the innovative research being done by our scientists and clinical collaborators.

TriSalus Clinical Essentials™

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End-hole Versus Microvalve Infusion Catheters in Patients Undergoing Drug-Eluting Microspheres-TACE for Solitary Hepatocellular Carcinoma Tumors: A Retrospective Analysis

Tags: Retrospective Study, Drug Delivery, Embolization

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Browse Publications & Presentations

  • Apr 2023
  • American Association for Cancer Research (AACR) / April 2023

PERIO-01: Initial safety experience and immunologic effects of a Class C TLR9 agonist using pressureenabled drug delivery in a phase 1 trial of hepatic arterial infusion of SD-101 +/- checkpoint inhibition in metastatic uveal melanoma

Sapna P. Patel , Cara Haymaker, Rahul A. Sheth, Joshua D. Kuban, Joshua Weintraub, Eric Wehrenberg-Klee, Paula Novelli, Carin Gonsalves, Robert Adamo, Virginia Honaker, Laura Timciuc, Tarin Hennegan, Juan C. Amador-Molina, Dzifa Duose, Edwin R. Parra, Anthony Lucci, Salyna Meas, Vanessa Sarli, Victor G. Prieto, Jason LaPorte, Ann-Marie Hulstine, Ashley Moody, Bryan Cox, David Geller, Diwakar Davar, Kamaneh Montazeri, Marlana Orloff, Steven C. Katz, Richard Carvajal
  • Apr 2023
  • American Association for Cancer Research (AACR) / April 2023

Enhanced delivery of anti PD-1 antibody to liver tumors in oncopig using pressure enabled drug delivery (PEDD) versus systemic delivery

David Jaroch, PhD; Chandra Ghosh, PhD; Prajna Guha, PhD; Steven C. Katz, MD; Bryan Cox, PhD; Thomas Hullinger, PhD TriSalus Life Sciences Inc., Department of Surgery, Brown University School of Medicine
  • Mar 2023
  • Society of Interventional Radiology (SIR) 2023 – (Late Breaking)

The effects of a pressure-enabled drug delivery microcatheter on radiotracer distribution compared to a standard microcatheter in radioembolization, an interim analysis

P. Sutphin, E. Wehrenberg-Klee, S. Kalva, R. Uppot, V. Wu
  • Mar 2023
  • Journal of Vascular and Interventional Radiology – Abstract 140

Hepatic Arterial Infusion of the Class C TLR9 Agonist SD-101 in Pressure Enabled Regional Immuno-Oncology (PERIO) Phase 1 Trials for Liver Tumors with authors.

R. Sheth, et al
  • Mar 2023
  • Society for Immunotherapy of Cancer (SITC) 2023

Pressure-enabled intravascular delivery of SD-101 into the liver with systemic or subcutaneous checkpoint inhibitor for control of liver metastases in a murine model

Chandra C. Ghosh, Lauren Cournoyer, Jennie Liu, Alizee Ballarin, Jason LaPorte, Prajna Guha, Bryan F. Cox, Steven C. Katz
  • Jan 2023
  • Society of Interventional Oncology (SIO) 2023

Enhanced Delivery of a TLR9 Type C Agonist SD-101 to Liver Tumors in the Oncopig using Pressure Enabled Drug Delivery (PEDD) Versus a Standard Endhole Catheter

Thomas Hullinger, PhD, Dennis Griffin, MD, David Porter, MD, James Luethke, MD, Steven Katz, MD, Bryan Cox, PhD, David Jaroch, PhD
Tags: Pre-clinical Study, Pressure-Enabled Regional Immunotherapy, TLR9 Agonist
  • Jun 2022
  • Journal of Interventional Radiology – Abstract 333

Improved delivery of a TLR-9 agonist to liver tissue by intravascular pressure enabled drug delivery (PEDD) compared with direct needle injection

D. Jaroch, et al
  • Jun 2022
  • Cancer Gene Therapy

Regional Infusion of a Class C TLR9 Agonist Enhances Liver Tumor Microenvironment Reprogramming and MDSC Reduction to Improve Responsiveness to Systemic Checkpoint Inhibition

Chandra C. Ghosh, Kara R. Heatherton, Kyle P. O’Connell, Ian S. Alexander, Deborah A. Greer, Jason LaPorte, Prajna Guha, Bryan F. Cox and Steven C. Katz
Tags: Pre-clinical Study, Pressure-Enabled Regional Immunotherapy, TLR9 Agonist
  • Apr 2022
  • Society for Immunotherapy of Cancer (SITC) 2022

Abstract No. 158628: PERIO-01: Enabling Tumor Microenvironment Reprogramming by a TLR9 Agonist Using Pressure-Enabled Drug Delivery™ (PEDD™) to Address Intrahepatic Immunosuppression and Drug Delivery Barriers

Sapna P. Patel, Steven C. Katz, Rahul A. Sheth, Ravi Murthy, Virginia Honaker, Chantell M. Farinas, Mara L. Casteneda, Laura Timciuc, Tarin Hennegan, Cara Haymaker, Victor G. Prieto, Bryan Cox, Ann-Marie Hulstine, Jason LaPorte, Ashley Moody, Marlana Orloff and Richard D. Carvajal
Tags: Clinical Trial, Pressure-Enabled Regional Immunotherapy, TLR9 Agonist
  • Nov 2021
  • Diagnostic and Interventional Radiology

Antireflux Catheter Improves Tumor Targeting in Liver Radioembolization with Resin Microspheres

Philippe d’Abadie, Stephan Walrand, Pierre Goffette, Nadia Amini, Aline van Maanen, Renaud Lhommel and François Jamar
Tags: Drug Delivery, Embolization, Retrospective Study
  • Apr 2021
  • Intrahepatic TLR9 Activation and Immunomodulation Compared to Systemic Infusion​

Abstract No. 1793: Regional Administration of Class C CpG Oligodeoxynucleotides Results in Superior Intrahepatic TLR9 Activation and Immunomodulation Compared to Systemic Infusion

Chandra C. Ghosh, Kara Heatherton, Kyle O’Connell, Jason LaPorte, Prajna Guha, Bryan F. Cox, David Jaroch and Steven C. Katz
Tags: Immunomodulation, Pre-clinical Trial, TLR9 Agonist
  • Aug 2020
  • Journal for Immunotherapy of Cancer

HITM-SURE: Hepatic Immunotherapy for Metastases Phase Ib Anti-CEA CAR-T Study Utilizing Pressure Enabled Drug Delivery

Steven C. Katz, Ashley E. Moody, Prajna Guha, John C. Hardaway, Ethan Prince, Jason LaPorte, Mirela Stancu, Jill E. Slansky, Kimberly R. Jordan, Richard D. Schulick, Robert Knight, Abdul Saied, Vincent Armenio and Richard P. Junghans
Tags: CAR-T, Case Report, Pressure-Enabled Regional Immunotherapy
  • Jun 2019
  • American Society of Clinical Oncology (ASCO) Annual Meeting

Abstract No. 9555: Phase 1b/2, Open Label, Multicenter Study of the Combination of SD-101 and Pembrolizumab in Patients with Advanced/Metastatic Melanoma Resistant to Anti-PD-1/PD-L1 Therapy (SYNERGY-001/KEYNOTE-184, NCT02521870)

A. Amin, G.V. Long, M. Milhem, C.J. Hoimes, T. Medina, R. M. Conry, C. Lao, G. Daniels, S. Reddy, R. H. I. Andtbacka, M. Barve, M. Shaheen, T. Tüting, M. Chisamore, E. Schmidt, B. Xing, C. Guiducci, C. Obiozor, T. Bagulho, E. Gamelin, R. Janssen and A. Ribas
Tags: Clinical Trial, Immunomodulation, TLR9 Agonist
  • Jan 2019
  • Oncogene

STAT3 Inhibition Induces Bax-dependent Apoptosis in Liver Tumor Myeloid-Derived Suppressor Cells

Prajna Guha, Jillian Gardell, Josephine Darpolor, Marissa Cunetta, Matthew Lima, George Miller, N. Joseph Espat, Richard P. Junghans and Steven C. Katz
Tags: Immunomodulation, Pre-clinical Study, TLR9 Agonist
  • Jan 2019
  • Cardiovascular and Interventional Radiology

End-hole Versus Microvalve Infusion Catheters in Patients Undergoing Drug-Eluting Microspheres-TACE for Solitary Hepatocellular Carcinoma Tumors: A Retrospective Analysis

Joseph J. Titano, Aaron M. Fischman, Arnav Cherian, Madeline Tully, Lance L. Stein, Louis Jacobs, Raymond A. Rubin, Michael Bosley, Steve Citron, Dean W. Joelson, Roshan Shrestha and Aravind Arepally
Tags: Drug Delivery, Embolization, Retrospective Study
  • Nov 2018
  • Society for Immunotherapy of Cancer (SITC) 2018

HITM-SURE: Phase Ib CAR-T Hepatic Artery Infusion Trial for Stage IV Adenocarcinoma using Pressure-Enabled Drug Delivery Technology

Steven C. Katz, Prajna Guha, John C. Hardaway, Ethan Prince, Ashley Moody, Jill E. Slansky, Kimberly R. Jordan, Richard D. Schulick, Robert Knight, Jerry Zeldis, Vincent Armenio, N. Joseph Espat and Richard P. Junghans
Tags: CAR-T, Clinical Trial, Drug Delivery
  • Apr 2018
  • Journal of Vascular and Interventional Radiology

Abstract No. 133: Surefire Infusion System (SIS) Hepatocellular Carcinoma Registry Study Interim Results: a Multicenter Study of the Safety, Feasibility, and Outcomes of the SIS Expandable-Tip Microcatheter in DEB-TACE

B. Kapoor, F. Contreras, M. Katz, A. Arepally, A. Fischman, S. Rose, A. Kim and J. Ferraro
Tags: Clinical Trial, Drug Delivery, Embolization
  • Sep 2017
  • PlOS One

Short-term Imaging Response after Drug-Eluting Embolic Trans-Arterial Chemoembolization Delivered with the Surefire Infusion System® for the Treatment of Hepatocellular Carcinoma

Alexander Y. Kim, Shelby Frantz, Pranay Krishnan, Danielle DeMulder, Theresa Caridi, George Emmett Lynskey and James B. Spies
Tags: Clinical Trial, Drug Delivery, Embolization
  • May 2015
  • Journal of Vascular and Interventional Radiology

The Impact of an Antireflux Catheter on Target Volume Particulate Distribution in Liver-Directed Embolotherapy: A Pilot Study

Alexander S. Pasciak, James H. McElmurray, Austin C. Bourgeois, R. Eric Heidel and Yong C. Bradley
Tags: Drug Delivery, Embolization, Prospective Study
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